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Fig. 3: Lots of genes activated by p53 also bind p53 within their promoters. A big portion of genes repressed on p53 induction binds RB-E2F, but essentially every one of these genes usually do not bind p53 in their promoters.
The intelligent biking method is executed depending upon the drying prerequisite and is particularly regulated in this kind of way that the swap-off occasions can be optimally prolonged.
This means that RB and p130 indirectly bind to precisely the same web pages and compete with or substitute for each other. Probably p130 is complexed in DREAM. This means a contest or substitution among RB-E2F and Aspiration. So, inactivation of one of many complexes could be compensated by the other. Nevertheless, redundant Management by RB-E2F and DREAM as described here is only possible when both complexes can easily bind E2F websites from the goal promoters.
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In conclusion, p53-p21-RB signaling contributes substantially to mobile cycle regulation. RB cooperates with Aspiration to result in oblique gene repression and cell cycle arrest pursuing p53 activation.
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Δεν βρήκαμε ομοιότητες με ιστότοπους απάτης που είχαν βρεθεί στο παρελθόν ή με δημοφιλείς ιστότοπους. Δεν εγγυάται ότι ο ιστότοπος είναι νόμιμος.